The combination of strategic factors for a successful prosthetic rehabilitation Designing full-mouth rehabilitations with optimum esthetics requires correct treatment planning, evaluation of a suitable ceramic material and skillful application and techniques. Today technology validly supports the clinician in the definition of an ideal treatment plan and in the optimization of time and costs. In particular the dentist can count on a digital tools that guide him/her in the step-by-step collection of all the necessary data. Selecting the ceramic material with the dental ceramist is another fundamental step in the management of complex rehabilitation cases. Thanks to the use of metal-free ceramic materials it is possible to obtain excellent esthetic results while reducing the need to remove sound tooth structure. Nowadays an innovative operative protocol allows the dentist to face highly compromised clinical situations with a minimally invasive prosthetic procedure. Thanks to the alteration of the of the vertical dimension of occlusion (VDO) it is possible to take advantage of the newly created space between the two arches with the result of minimizing the invasiveness of the prosthetic treatment when using veneers, full-veneers, buccal-occlusal veneers and table tops, even with very reduced ceramic thickness. This Minimally Invasive Prosthetic Procedure (MIPP) permits to re-establish an ideal occlusal relationship and to avoid additional endodontic or surgical steps that were traditionally necessary in order to improve the retention of the restorations. The maintenance of a maximum amount of enamel and the use of the appropriate bonding technique guarantee a remarkable resistance and a long-lasting result of the prosthetic rehabilitation.